Neuroblastoma

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  • most common malignant neoplasm affecting infants less than 1 year of age
  • arises from the neural crest (MCQ)
  • most commonly found in the adrenal medulla (MCQ)
  • it may arise anywhere along the sympathetic chain, including the neck.
  • Abdominal mass and fever are presenting signs.
  • Some are incidentally found by prenatal ultrasound.
  • Diffusely metastatic tumors to liver, bone marrow, and skin produce the
  • so-called ‘blueberry muffin’ clinical appearance. (MCQ)
  • Neuroblastomas secrete catecholamines
    • vanillylmandelic acid [VMA]
    • homovanillic acid [HVA])
  • urine testing for these compounds can confirm the diagnosis and monitor for recurrence.
  • Microscopically, these tumors are arranged in sheets and pseudorosettes of
  • small round blue cells. (MCQ)
  • Tumor cells immunostain for neuroendocrine markers, such as chromo-
  • granin. (MCQ)
  • In time, or after treatment, these tumors may mature revealing ganglion cells and mature neural tissue.
  • Genetic aberrations include
    • deletion of 1p(MCQ)
    • N-myc gene amplification
    • hyperdiploidy.
  • N-myc amplification is associated with aggressive behavior(MCQ)
  • Hyperdiploidy is associated with a better prognosis. (MCQ)


Laparoscopic excision of Rt. Neuroblastoma in 1 month old child-Final
Lap Neuroblastoma Resection.mov
Laparoscopic resection of two tumor deposits in 5 year old child with high risk neuroblastoma
Neuroblastoma Childhood cancer Awareness 2014
hank you to my friends who donated video and Pictures to us to make this video. My son Elijah was Diagnosed at age 3 with Stage 4 high risk Neuroblastoma and is on his 2nd relapse 2014.
Neuroblastoma made easy
Neuroblastoma easy as 1 2 3
Histopathology Adrenal–Neuroblastoma
Histopathology Adrenal–Neuroblastoma